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Estrogen restores postischemic pial microvascular dilation

Estrogen protects the brain from experimental cerebral ischemia, likely through both vascular and neuronal cellular mechanisms. The purpose of this study was to determine whether chronic estrogen treatment in males and repletion in ovariectomized (Ovx) females reverses abnormalities in pial arteriol...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-07, Vol.50 (1), p.H155-H160
Main Authors: WATANABE, Y, LITTLETON-KEARNEY, M. T, TRAYSTMAN, R. J, HURN, P. D
Format: Article
Language:English
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Summary:Estrogen protects the brain from experimental cerebral ischemia, likely through both vascular and neuronal cellular mechanisms. The purpose of this study was to determine whether chronic estrogen treatment in males and repletion in ovariectomized (Ovx) females reverses abnormalities in pial arteriolar reactivity during reperfusion from global forebrain ischemia (4-vessel occlusion, 15 min) and whether the site of protection is vascular endothelium.
ISSN:0363-6135
1522-1539