Estrogen restores postischemic pial microvascular dilation

Estrogen protects the brain from experimental cerebral ischemia, likely through both vascular and neuronal cellular mechanisms. The purpose of this study was to determine whether chronic estrogen treatment in males and repletion in ovariectomized (Ovx) females reverses abnormalities in pial arteriol...

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Published in:American journal of physiology. Heart and circulatory physiology 2001-07, Vol.50 (1), p.H155-H160
Main Authors: WATANABE, Y, LITTLETON-KEARNEY, M. T, TRAYSTMAN, R. J, HURN, P. D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain
Estrogens
Females
Males
Medical sciences
Neuropharmacology
Neuroprotective agent
Pathology
Pharmacology. Drug treatments
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container_title American journal of physiology. Heart and circulatory physiology
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creator WATANABE, Y
LITTLETON-KEARNEY, M. T
TRAYSTMAN, R. J
HURN, P. D
description Estrogen protects the brain from experimental cerebral ischemia, likely through both vascular and neuronal cellular mechanisms. The purpose of this study was to determine whether chronic estrogen treatment in males and repletion in ovariectomized (Ovx) females reverses abnormalities in pial arteriolar reactivity during reperfusion from global forebrain ischemia (4-vessel occlusion, 15 min) and whether the site of protection is vascular endothelium.
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source American Physiological Society Free
subjects Biological and medical sciences
Brain
Estrogens
Females
Males
Medical sciences
Neuropharmacology
Neuroprotective agent
Pathology
Pharmacology. Drug treatments
title Estrogen restores postischemic pial microvascular dilation
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