Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity

Hindlimb unloading of rats results in a diminished ability of skeletal muscle arterioles to constrict in vitro and elevate vascular resistance in vivo. The purpose of the present study was to determine whether alterations in the mechanical environment (i.e., reduced fluid pressure and blood flow) of...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-06, Vol.47 (6), p.H1866-H1873
Main Authors: DELP, M. D, COLLERAN, P. N, WILKERSON, M. K, MCCURDY, M. R, MULLER-DELP, J
Format: Article
Language:English
Subjects:
Applied physiology
Biological and medical sciences
Human physiology applied to population studies and life conditions. Human ecophysiology
Medical sciences
Muscular system
Simulation
Skeletal system
Transports. Aerospace. Diving. Altitude
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hindlimb unloading of rats results in a diminished ability of skeletal muscle arterioles to constrict in vitro and elevate vascular resistance in vivo. The purpose of the present study was to determine whether alterations in the mechanical environment (i.e., reduced fluid pressure and blood flow) of the vasculature in hindlimb skeletal muscles from 2-wk hindlimb-unloaded (HU) rats induces a structural remodeling of arterial microvessels that may account for these observations.
ISSN:0363-6135
1522-1539