Temporal gradient in shear-induced signaling pathway : Involvement of MAP kinase, c-fos, and connexin43

The effect of a temporal gradient in shear and steady shear on the activity of extracellular signal-regulated protein kinases 1 and 2 (ERK1/ERK2), c-fos, and connexin43 (Cx43) in human endothelial cells was investigated. Three laminar flow profiles (16 dyn/cm(2)), including impulse flow (shear stres...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-05, Vol.47 (5), p.H1598-H1605
Main Authors: XUPING BAO, CLARK, C. B, FRANGOS, J. A
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Blood vessels and receptors
Cells
Fundamental and applied biological sciences. Psychology
Genes
Vertebrates: cardiovascular system
Online Access:Get full text
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Summary:The effect of a temporal gradient in shear and steady shear on the activity of extracellular signal-regulated protein kinases 1 and 2 (ERK1/ERK2), c-fos, and connexin43 (Cx43) in human endothelial cells was investigated. Three laminar flow profiles (16 dyn/cm(2)), including impulse flow (shear stress abruptly applied for 3 s), ramp flow (shear stress smoothly transitioned at flow onset), and step flow (shear stress abruptly applied at flow onset) were utilized.
ISSN:0363-6135
1522-1539