Niacin protects the isolated heart from ischemia-reperfusion injury

Nicotinic acid (niacin) has been shown to decrease myocyte injury. Because interventions that lower the cytosolic NADH/NAD(+) ratio inprove glycolysis and limit infarct size, we hypothesized that 1) niacin, as a precursor of NAD(+), would lower the NADH/NAD(+) ratio, increase glycolysis, and limit i...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-08, Vol.48 (2), p.H764-H771
Main Authors: TRUEBLOOD, N. A, RAMASAMY, R, LI FENG WANG, SCHAEFER, S
Format: Article
Language:English
Subjects:
Biochemistry
Biological and medical sciences
Cardiovascular system
Heart
Injuries
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page H771
container_issue 2
container_start_page H764
container_title American journal of physiology. Heart and circulatory physiology
container_volume 48
creator TRUEBLOOD, N. A
RAMASAMY, R
LI FENG WANG
SCHAEFER, S
description Nicotinic acid (niacin) has been shown to decrease myocyte injury. Because interventions that lower the cytosolic NADH/NAD(+) ratio inprove glycolysis and limit infarct size, we hypothesized that 1) niacin, as a precursor of NAD(+), would lower the NADH/NAD(+) ratio, increase glycolysis, and limit ischemic injury and 2) these cardioprotective benefits of niacin would be limited in conditions that block lactate removal.
format article
fullrecord <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_journals_229602583</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>60239335</sourcerecordid><originalsourceid>FETCH-LOGICAL-p563-2a33008241925d74e11c0e8647393f53424ff3d66b587d3e2c25fc35747b63bb3</originalsourceid><addsrcrecordid>eNotkE1LxDAYhIMouK7-hyJeC0nefLRHKX7Bope9lzR9Q1P6ZZIe9t8bcE8DwzDPMDfkwCTnJZNQ35IDBQWlYiDvyUOMI6VUagUH0nx7Y_1SbGFNaFMs0oCFj-tkEvbFgCakwoV1zp4dcPamDLhhcHv061L4ZdzD5ZHcOTNFfLrqkZzf387NZ3n6-fhqXk_lJjOcGwBKKy5YzWWvBTJmKVZKaKjBSRBcOAe9Up2sdA_ILZfOgtRCdwq6Do7k-b82b_3dMaZ2XPewZGLLea0olxXk0Ms1ZKI1kwtmsT62W_CzCZeWCa1FvuQP5YpSqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229602583</pqid></control><display><type>article</type><title>Niacin protects the isolated heart from ischemia-reperfusion injury</title><source>American Physiological Society Free</source><creator>TRUEBLOOD, N. A ; RAMASAMY, R ; LI FENG WANG ; SCHAEFER, S</creator><creatorcontrib>TRUEBLOOD, N. A ; RAMASAMY, R ; LI FENG WANG ; SCHAEFER, S</creatorcontrib><description>Nicotinic acid (niacin) has been shown to decrease myocyte injury. Because interventions that lower the cytosolic NADH/NAD(+) ratio inprove glycolysis and limit infarct size, we hypothesized that 1) niacin, as a precursor of NAD(+), would lower the NADH/NAD(+) ratio, increase glycolysis, and limit ischemic injury and 2) these cardioprotective benefits of niacin would be limited in conditions that block lactate removal.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Biochemistry ; Biological and medical sciences ; Cardiovascular system ; Heart ; Injuries ; Medical sciences ; Miscellaneous ; Pharmacology. Drug treatments</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2000-08, Vol.48 (2), p.H764-H771</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Physiological Society Aug 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1477415$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>TRUEBLOOD, N. A</creatorcontrib><creatorcontrib>RAMASAMY, R</creatorcontrib><creatorcontrib>LI FENG WANG</creatorcontrib><creatorcontrib>SCHAEFER, S</creatorcontrib><title>Niacin protects the isolated heart from ischemia-reperfusion injury</title><title>American journal of physiology. Heart and circulatory physiology</title><description>Nicotinic acid (niacin) has been shown to decrease myocyte injury. Because interventions that lower the cytosolic NADH/NAD(+) ratio inprove glycolysis and limit infarct size, we hypothesized that 1) niacin, as a precursor of NAD(+), would lower the NADH/NAD(+) ratio, increase glycolysis, and limit ischemic injury and 2) these cardioprotective benefits of niacin would be limited in conditions that block lactate removal.</description><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Heart</subject><subject>Injuries</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Pharmacology. Drug treatments</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNotkE1LxDAYhIMouK7-hyJeC0nefLRHKX7Bope9lzR9Q1P6ZZIe9t8bcE8DwzDPMDfkwCTnJZNQ35IDBQWlYiDvyUOMI6VUagUH0nx7Y_1SbGFNaFMs0oCFj-tkEvbFgCakwoV1zp4dcPamDLhhcHv061L4ZdzD5ZHcOTNFfLrqkZzf387NZ3n6-fhqXk_lJjOcGwBKKy5YzWWvBTJmKVZKaKjBSRBcOAe9Up2sdA_ILZfOgtRCdwq6Do7k-b82b_3dMaZ2XPewZGLLea0olxXk0Ms1ZKI1kwtmsT62W_CzCZeWCa1FvuQP5YpSqw</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>TRUEBLOOD, N. A</creator><creator>RAMASAMY, R</creator><creator>LI FENG WANG</creator><creator>SCHAEFER, S</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20000801</creationdate><title>Niacin protects the isolated heart from ischemia-reperfusion injury</title><author>TRUEBLOOD, N. A ; RAMASAMY, R ; LI FENG WANG ; SCHAEFER, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p563-2a33008241925d74e11c0e8647393f53424ff3d66b587d3e2c25fc35747b63bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Heart</topic><topic>Injuries</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TRUEBLOOD, N. A</creatorcontrib><creatorcontrib>RAMASAMY, R</creatorcontrib><creatorcontrib>LI FENG WANG</creatorcontrib><creatorcontrib>SCHAEFER, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TRUEBLOOD, N. A</au><au>RAMASAMY, R</au><au>LI FENG WANG</au><au>SCHAEFER, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Niacin protects the isolated heart from ischemia-reperfusion injury</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><date>2000-08-01</date><risdate>2000</risdate><volume>48</volume><issue>2</issue><spage>H764</spage><epage>H771</epage><pages>H764-H771</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><abstract>Nicotinic acid (niacin) has been shown to decrease myocyte injury. Because interventions that lower the cytosolic NADH/NAD(+) ratio inprove glycolysis and limit infarct size, we hypothesized that 1) niacin, as a precursor of NAD(+), would lower the NADH/NAD(+) ratio, increase glycolysis, and limit ischemic injury and 2) these cardioprotective benefits of niacin would be limited in conditions that block lactate removal.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record>
fulltext fulltext
identifier ISSN: 0363-6135
ispartof American journal of physiology. Heart and circulatory physiology, 2000-08, Vol.48 (2), p.H764-H771
issn 0363-6135
1522-1539
language eng
recordid cdi_proquest_journals_229602583
source American Physiological Society Free
subjects Biochemistry
Biological and medical sciences
Cardiovascular system
Heart
Injuries
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
title Niacin protects the isolated heart from ischemia-reperfusion injury
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T01%3A33%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Niacin%20protects%20the%20isolated%20heart%20from%20ischemia-reperfusion%20injury&rft.jtitle=American%20journal%20of%20physiology.%20Heart%20and%20circulatory%20physiology&rft.au=TRUEBLOOD,%20N.%20A&rft.date=2000-08-01&rft.volume=48&rft.issue=2&rft.spage=H764&rft.epage=H771&rft.pages=H764-H771&rft.issn=0363-6135&rft.eissn=1522-1539&rft.coden=AJPPDI&rft_id=info:doi/&rft_dat=%3Cproquest_pasca%3E60239335%3C/proquest_pasca%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p563-2a33008241925d74e11c0e8647393f53424ff3d66b587d3e2c25fc35747b63bb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=229602583&rft_id=info:pmid/&rfr_iscdi=true