Mitochondrial ATPase and high-energy phosphates in failing hearts

This study examined high-energy phosphates (HEP) and mitochondrial ATPase protein expression in hearts in which myocardial infarction resulted in either compensated left ventricular remodeling (LVR) or congestive heart failure (CHF). The response of HEP (measured via 31P magnetic resonance spectrosc...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-09, Vol.50 (3), p.H1319-H1326
Main Authors: JINGBO LIU, CHUNSHENG WANG, MURAKAMI, Y. O, GUANGRONG GONG, ISHIBASHI, Yutaka, PRODY, Catherine, OCHIAI, Koichi, BACHE, Robert J, GODINOT, Catherine, JIANYI ZHANG
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood vessels
Cardiology
Cardiology. Vascular system
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Medical sciences
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Summary:This study examined high-energy phosphates (HEP) and mitochondrial ATPase protein expression in hearts in which myocardial infarction resulted in either compensated left ventricular remodeling (LVR) or congestive heart failure (CHF). The response of HEP (measured via 31P magnetic resonance spectroscopy) to a modest increase in the cardiac work state produced by dobutamine-dopamine infusion and pacing (if needed) was examined in 17 pigs after left circumflex coronary artery ligation (9 with LVR and 8 with CHF) and compared with 7 normal pigs.
ISSN:0363-6135
1522-1539