Low-dose ramipril treatment improves relaxation and calcium cycling after established cardiac hypertrophy

Rapid cooling contractures were used in this study to test whether low-dose ramipril improves sarcoplasmic reticulum (SR) Ca2+ uptake and Na+/Ca2+ exchanger function in isolated hypertrophied rat myocytes. Compensated cardiac hypertrophy was induced by abdominal aortic constriction for 5 wk followed...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-03, Vol.49 (3), p.H1029-H1038
Main Authors: BOATENG, Samuel Y, NAQVI, Ruby U, KOBAN, Maren U, YACOUB, Magdi H, MACLEOD, Kenneth T, BOHELER, Kenneth R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Caffeine
Calcium
Cardiovascular disease
Cardiovascular system
Cells
Clinical trials
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Proteins
Ribonucleic acid
RNA
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Summary:Rapid cooling contractures were used in this study to test whether low-dose ramipril improves sarcoplasmic reticulum (SR) Ca2+ uptake and Na+/Ca2+ exchanger function in isolated hypertrophied rat myocytes. Compensated cardiac hypertrophy was induced by abdominal aortic constriction for 5 wk followed by administration of ramipril (50 mug.kg-1.
ISSN:0363-6135
1522-1539