Hemorrhage-induced α-adrenergic signaling results in myocardial TNF-α expression and contractile dysfunction

Hemorrhagic shock (HS), secondary to major blood loss, frequently precedes multiple organ dysfunction and is accompanied by a surge in circulating catecholamine levels. Expression of the cardiodepressant cytokine, tumor necrosis factor-alpha (TNF-alpha), has been observed in the heart after HS and r...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-07, Vol.50 (1), p.H84-H92
Main Authors: SHAHANI, Rohan, KLEIN, Lazar V, MARSHALL, John G, NICHOLSON, Sherwin, RUBIN, Barry B, WALKER, Paul M, LINDSAY, Thomas F
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood vessels
Cardiovascular disease
Cytokines
Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition
Heart
Hemorrhage
Intensive care medicine
Medical sciences
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Summary:Hemorrhagic shock (HS), secondary to major blood loss, frequently precedes multiple organ dysfunction and is accompanied by a surge in circulating catecholamine levels. Expression of the cardiodepressant cytokine, tumor necrosis factor-alpha (TNF-alpha), has been observed in the heart after HS and resuscitation (HS/;R) and alpha1-adrenergic blockade prevented translocation of the nuclear transcription factor, NF-kB, to the nucleus.
ISSN:0363-6135
1522-1539