Estrogen replacement, vascular distensibility, and blood pressures in postmenopausal women

The pathogenesis of blood pressure (BP) rise in aging women remains unexplained, nd one of the many incriminating factors may include abnormalities in arteriolar resistance vessels. The aim of this study was to determine the effects of unopposed estrogen on arteriolar distensibility, baroreceptor se...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1998-05, Vol.43 (5), p.H1539-H1544
Main Authors: DE MEERSMAN, R. E, ZION, A. S, GIARDINA, E. G. V, WEIR, J. P, LIEBERMAN, J. S, DOWNEY, J. A
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Blood pressure
Circulatory system
Estrogens
Hormones. Endocrine system
Medical sciences
Pharmacology. Drug treatments
Women
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Summary:The pathogenesis of blood pressure (BP) rise in aging women remains unexplained, nd one of the many incriminating factors may include abnormalities in arteriolar resistance vessels. The aim of this study was to determine the effects of unopposed estrogen on arteriolar distensibility, baroreceptor sensitivity (BRS), BP changes, and rate-pressure product (RPP). We tested the hypotheses that estrogen replacement therapy (ERT) enhances arteriolar distensibility and ameliorates BRS, which leads to decreases in BP and RPP.
ISSN:0363-6135
1522-1539