Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow

Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intrav...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-12, Vol.48 (6), p.H2954-H2960
Main Authors: SUWA, Tatsushi, HOGG, James C, ENGLISH, Dean, VAN EEDEN, Stephan F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood
Bone marrow
Circulatory system
Hematologic and hematopoietic diseases
Leukocytes
Medical sciences
Other diseases. Hematologic involvement in other diseases
Proteins
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Summary:Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intravascular demargination to the IL-6 induced neutrophilia.
ISSN:0363-6135
1522-1539