Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow

Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intrav...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-12, Vol.48 (6), p.H2954-H2960
Main Authors: SUWA, Tatsushi, HOGG, James C, ENGLISH, Dean, VAN EEDEN, Stephan F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood
Bone marrow
Circulatory system
Hematologic and hematopoietic diseases
Leukocytes
Medical sciences
Other diseases. Hematologic involvement in other diseases
Proteins
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page H2960
container_issue 6
container_start_page H2954
container_title American journal of physiology. Heart and circulatory physiology
container_volume 48
creator SUWA, Tatsushi
HOGG, James C
ENGLISH, Dean
VAN EEDEN, Stephan F
description Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intravascular demargination to the IL-6 induced neutrophilia.
format article
fullrecord <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_journals_229631361</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67391097</sourcerecordid><originalsourceid>FETCH-LOGICAL-p551-fcbd6154288519a2d503812392cbc0736a96de4671defbe60a2857a315f8058c3</originalsourceid><addsrcrecordid>eNotkE9PAyEQxYnRxLr6HYieNwGmsOzRNP5p0sRL7xsKs5a6wgqsxm8viT3NYd6893tzQVZcCtFyCf0lWTFQ0CoO8prc5HxijMlOwYrgNhRMEy4fPrSK-uAWi5k6_DTp3QdTfAw0jnVRkvk22S6TSTTgUlKcj37K1ARH8zGmgiHTckSfaJWG7Es9otUmxZ9bcjWaKePdeTZk__y037y2u7eX7eZx185S8na0B6e4XAutJe-NcJKB5gJ6YQ-WdaBMrxyuVccdjgdUzAgtOwNcjppJbaEh9_-2c4pfC-YynOKSQk0chOgVcKgfaMjDWVTbmGmsrNbnYU6-sv4Oeg2VAP4AZRBgQA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229631361</pqid></control><display><type>article</type><title>Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow</title><source>American Physiological Society Journals</source><creator>SUWA, Tatsushi ; HOGG, James C ; ENGLISH, Dean ; VAN EEDEN, Stephan F</creator><creatorcontrib>SUWA, Tatsushi ; HOGG, James C ; ENGLISH, Dean ; VAN EEDEN, Stephan F</creatorcontrib><description>Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intravascular demargination to the IL-6 induced neutrophilia.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Biological and medical sciences ; Blood ; Bone marrow ; Circulatory system ; Hematologic and hematopoietic diseases ; Leukocytes ; Medical sciences ; Other diseases. Hematologic involvement in other diseases ; Proteins</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2000-12, Vol.48 (6), p.H2954-H2960</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Dec 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=843542$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>SUWA, Tatsushi</creatorcontrib><creatorcontrib>HOGG, James C</creatorcontrib><creatorcontrib>ENGLISH, Dean</creatorcontrib><creatorcontrib>VAN EEDEN, Stephan F</creatorcontrib><title>Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow</title><title>American journal of physiology. Heart and circulatory physiology</title><description>Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intravascular demargination to the IL-6 induced neutrophilia.</description><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Circulatory system</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Leukocytes</subject><subject>Medical sciences</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Proteins</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNotkE9PAyEQxYnRxLr6HYieNwGmsOzRNP5p0sRL7xsKs5a6wgqsxm8viT3NYd6893tzQVZcCtFyCf0lWTFQ0CoO8prc5HxijMlOwYrgNhRMEy4fPrSK-uAWi5k6_DTp3QdTfAw0jnVRkvk22S6TSTTgUlKcj37K1ARH8zGmgiHTckSfaJWG7Es9otUmxZ9bcjWaKePdeTZk__y037y2u7eX7eZx185S8na0B6e4XAutJe-NcJKB5gJ6YQ-WdaBMrxyuVccdjgdUzAgtOwNcjppJbaEh9_-2c4pfC-YynOKSQk0chOgVcKgfaMjDWVTbmGmsrNbnYU6-sv4Oeg2VAP4AZRBgQA</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>SUWA, Tatsushi</creator><creator>HOGG, James C</creator><creator>ENGLISH, Dean</creator><creator>VAN EEDEN, Stephan F</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20001201</creationdate><title>Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow</title><author>SUWA, Tatsushi ; HOGG, James C ; ENGLISH, Dean ; VAN EEDEN, Stephan F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p551-fcbd6154288519a2d503812392cbc0736a96de4671defbe60a2857a315f8058c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>Circulatory system</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Leukocytes</topic><topic>Medical sciences</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUWA, Tatsushi</creatorcontrib><creatorcontrib>HOGG, James C</creatorcontrib><creatorcontrib>ENGLISH, Dean</creatorcontrib><creatorcontrib>VAN EEDEN, Stephan F</creatorcontrib><collection>Pascal-Francis</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUWA, Tatsushi</au><au>HOGG, James C</au><au>ENGLISH, Dean</au><au>VAN EEDEN, Stephan F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><date>2000-12-01</date><risdate>2000</risdate><volume>48</volume><issue>6</issue><spage>H2954</spage><epage>H2960</epage><pages>H2954-H2960</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><abstract>Recombinant human interleukin-6 (IL-6) causes both a thrombocytosis and leukocytosis. The thrombocytosis is caused by an accelerating thrombocytopoiesis, but the mechanism of the leukocytosis is unknown. This study was designed to determine the relative contributions of marrow stimulation and intravascular demargination to the IL-6 induced neutrophilia.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record>
fulltext fulltext
identifier ISSN: 0363-6135
ispartof American journal of physiology. Heart and circulatory physiology, 2000-12, Vol.48 (6), p.H2954-H2960
issn 0363-6135
1522-1539
language eng
recordid cdi_proquest_journals_229631361
source American Physiological Society Journals
subjects Biological and medical sciences
Blood
Bone marrow
Circulatory system
Hematologic and hematopoietic diseases
Leukocytes
Medical sciences
Other diseases. Hematologic involvement in other diseases
Proteins
title Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T16%3A13%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin-6%20induces%20demargination%20of%20intravascular%20neutrophils%20and%20shortens%20their%20transit%20in%20marrow&rft.jtitle=American%20journal%20of%20physiology.%20Heart%20and%20circulatory%20physiology&rft.au=SUWA,%20Tatsushi&rft.date=2000-12-01&rft.volume=48&rft.issue=6&rft.spage=H2954&rft.epage=H2960&rft.pages=H2954-H2960&rft.issn=0363-6135&rft.eissn=1522-1539&rft.coden=AJPPDI&rft_id=info:doi/&rft_dat=%3Cproquest_pasca%3E67391097%3C/proquest_pasca%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p551-fcbd6154288519a2d503812392cbc0736a96de4671defbe60a2857a315f8058c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=229631361&rft_id=info:pmid/&rfr_iscdi=true