Tetrahydrobiopterin : a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?

As the result of several clinical studies, it has become evident that endothelial dysfunction is of prognostic significance. Nevertheless, there have been no large clinical trials demonstrating that treatment of endothelial dysfunction improves the prognosis. A manipulation of the metabolism of tetr...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-06, Vol.49 (6), p.H2484-H2488
Main Author: TIEFENBACHER, Christiane P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood vessels
Cardiovascular system
Cells
Medical sciences
Metabolism
Miscellaneous
Pharmacology. Drug treatments
Online Access:Get full text
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Summary:As the result of several clinical studies, it has become evident that endothelial dysfunction is of prognostic significance. Nevertheless, there have been no large clinical trials demonstrating that treatment of endothelial dysfunction improves the prognosis. A manipulation of the metabolism of tetrahydorbiopterin may be promising with regard to the treatment of endothelial dysfunction in the future.
ISSN:0363-6135
1522-1539