Metabolically healthy versus unhealthy obesity and risk of fibrosis progression in non‐alcoholic fatty liver disease

Background & Aims Little is known about the impact of metabolically healthy obesity on fibrosis progression in non‐alcoholic fatty liver disease (NAFLD). We investigated the association of body mass index (BMI) category, body fat percentage and waist circumference with worsening of noninvasive f...

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Bibliographic Details
Published in:Liver international 2019-10, Vol.39 (10), p.1884-1894
Main Authors: Kim, Yejin, Chang, Yoosoo, Cho, Yong Kyun, Ahn, Jiin, Shin, Hocheol, Ryu, Seungho
Format: Article
Language:English
Subjects:
Adipose tissue
Body fat
Body mass
Body mass index
Body size
Cohort analysis
cohort study
Fatty liver
Fibrosis
Insulin
Liver
Liver diseases
Markers
Metabolic disorders
metabolic health
Metabolic syndrome
Metabolism
non‐alcoholic fatty liver disease
Obesity
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Summary:Background & Aims Little is known about the impact of metabolically healthy obesity on fibrosis progression in non‐alcoholic fatty liver disease (NAFLD). We investigated the association of body mass index (BMI) category, body fat percentage and waist circumference with worsening of noninvasive fibrosis markers in metabolically healthy and unhealthy individuals with NAFLD. Methods A cohort study was performed on 59 957 Korean adults with NAFLD (13 285 metabolically healthy and 46 672 metabolically unhealthy individuals) who were followed for a median of 7.7 years. Being metabolically healthy was defined as not having any metabolic syndrome component and having a homoeostasis model assessment of insulin resistance
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.14184