Extracellular serotonin changes in VLM during muscle contraction : effects of 5-HT1A-receptor activation

This study determined whether muscle contraction causes an increase in extracellular levels of serotonin (5-HT) in t e rostral (rVLM) or caudal ventrolateral medulla (cVLM) in anesthetized rats. Muscle contraction, evoked bytibial nerve stimulation, increased mean arterial blood pressure (MAP) by 27...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1997-12, Vol.42 (6), p.H2899-H2909
Main Authors: ASMUNDSSON, G, CARINGI, D, MOKLER, D. J, KOBAYASHI, T, ISHIDE, T, ALLY, A
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Blood pressure
Circulatory system
Fundamental and applied biological sciences. Psychology
Heart
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Vertebrates: nervous system and sense organs
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Summary:This study determined whether muscle contraction causes an increase in extracellular levels of serotonin (5-HT) in t e rostral (rVLM) or caudal ventrolateral medulla (cVLM) in anesthetized rats. Muscle contraction, evoked bytibial nerve stimulation, increased mean arterial blood pressure (MAP) by 27 4mmHg (n = 8). In addition, 5-HT levels in the rVLM were elevated by 65 9% during the contraction (n = 8). Results were similar over two repeated contractions.
ISSN:0363-6135
1522-1539