Effects of ionic channel antagonists barium, cesium, and UL-FS-49 on vagal slowing of atrial rate in dogs

Wallick et al used dogs to determine the effects of three antagonists--barium, cesium, and UL-FS-49--to two ionic channels on the charasteristic triphasic pacemaker response after a vagal stimulus is administered. Cesium and UL-FS-49 did not affect the initial vagal slowing of atrial rate but abolis...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1997-11, Vol.42 (5), p.H2155-H2160
Main Authors: WALLICK, D. W, KUGUOGLU, A, YANG, T, STUESSE, S. L, LEVY, M. N
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dogs
Fundamental and applied biological sciences. Psychology
Heart
Nervous system
Vertebrates: cardiovascular system
Online Access:Get full text
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Summary:Wallick et al used dogs to determine the effects of three antagonists--barium, cesium, and UL-FS-49--to two ionic channels on the charasteristic triphasic pacemaker response after a vagal stimulus is administered. Cesium and UL-FS-49 did not affect the initial vagal slowing of atrial rate but abolished the acceleratory portion of the response.
ISSN:0363-6135
1522-1539