ANG II-related myocardial damage : role of cardiac sympathetic catecholamines and β-receptor regulation

The objectives of this study were 1) to determine whether ANG II-induced myocardial damage (ANG Dam) is mediated via the beta1-adrenergic receptor, 2) to elucidate whether adrenal medulla or cardiac sympathetic neuron catecholamines are responsible for ANG Dam, and 3) to determine whether the lack o...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1998-08, Vol.44 (2), p.H534-H541
Main Authors: HENEGAR, J. R, SCHWARTZ, D. D, JANICKI, J. S
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cardiovascular disease
Fundamental and applied biological sciences. Psychology
Heart
Vertebrates: cardiovascular system
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Summary:The objectives of this study were 1) to determine whether ANG II-induced myocardial damage (ANG Dam) is mediated via the beta1-adrenergic receptor, 2) to elucidate whether adrenal medulla or cardiac sympathetic neuron catecholamines are responsible for ANG Dam, and 3) to determine whether the lack of damage after 3 days of elevated ANG II levels is due to beta1-receptor downregulation. To this end, ANG II was administered to rats 1) that were treated with a beta-receptor blocker, 2) after adrenal medullectomy and/or cardiac sympathectomy, and 3) for 3 or 8 days.
ISSN:0363-6135
1522-1539