Aldose reductase inhibition improves altered glucose metabolism of isolated diabetic rat hearts

Alterations in glucose metabolism have been implicated in the cardiovascular complications of diabetes. Previous work in this laboratory demonstrated that hearts from diabetic animals have an elevated cytosolic redox ratio (NADH/NAD+) and that this redox imbalance is probably due to elevated polyol...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1998-07, Vol.44 (1), p.H75-H83
Main Authors: TRUEBLOOD, N, RAMASAMY, R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diabetes
Fundamental and applied biological sciences. Psychology
Glucose
Heart
Metabolism
Rodents
Vertebrates: cardiovascular system
Online Access:Get full text
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Summary:Alterations in glucose metabolism have been implicated in the cardiovascular complications of diabetes. Previous work in this laboratory demonstrated that hearts from diabetic animals have an elevated cytosolic redox ratio (NADH/NAD+) and that this redox imbalance is probably due to elevated polyol pathway flux.
ISSN:0363-6135
1522-1539