Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway

Previous studies have shown that administration of nitric oxide (NO) donors induces a delayed cardioprotective effect indistinguishable from the late phase of ischemic preconditioning (PC). However, the ability of clinically relevant NO donors to elicit this phenomenon has not been evaluated.

Saved in:
Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1999-12, Vol.46 (6), p.H2488-H2494
Main Authors: BANERJEE, S, TANG, X.-L, YUMIN QIU, TAKANO, H, MANCHIKALAPUDI, S, DAWN, B, SHIRK, G, BOLLI, R
Format: Article
Language:English
Subjects:
Anatomy & physiology
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Cardiovascular disease
Cardiovascular system
Medical sciences
Nitrates
Pharmacology. Drug treatments
Proteins
Rabbits
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have shown that administration of nitric oxide (NO) donors induces a delayed cardioprotective effect indistinguishable from the late phase of ischemic preconditioning (PC). However, the ability of clinically relevant NO donors to elicit this phenomenon has not been evaluated.
ISSN:0363-6135
1522-1539