PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes

We have previously shown that protein kinase C (PKC)-epsilon, nuclear factor (NF)-kappaB, and mitogen-activated protein kinases (MAPKs) are essential signaling elements in ischemic preconditioning. In the present study, we examined whether activation of PKCepsilon affects the activation of NF-kappaB...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-10, Vol.48 (4), p.H1679
Main Authors: Li, Richard C X, Peipei Ping, Zhang, Jun, Wead, William B
Format: Article
Language:English
Subjects:
Circulatory system
Proteins
Rabbits
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Summary:We have previously shown that protein kinase C (PKC)-epsilon, nuclear factor (NF)-kappaB, and mitogen-activated protein kinases (MAPKs) are essential signaling elements in ischemic preconditioning. In the present study, we examined whether activation of PKCepsilon affects the activation of NF-kappaB in cardiac myocytes and whether MAPKs are mediators of this signaling event.
ISSN:0363-6135
1522-1539