PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes

We have previously shown that protein kinase C (PKC)-epsilon, nuclear factor (NF)-kappaB, and mitogen-activated protein kinases (MAPKs) are essential signaling elements in ischemic preconditioning. In the present study, we examined whether activation of PKCepsilon affects the activation of NF-kappaB...

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Published in:American journal of physiology. Heart and circulatory physiology 2000-10, Vol.48 (4), p.H1679
Main Authors: Li, Richard C X, Peipei Ping, Zhang, Jun, Wead, William B
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Language:English
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Circulatory system
Proteins
Rabbits
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container_title American journal of physiology. Heart and circulatory physiology
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creator Li, Richard C X
Peipei Ping
Zhang, Jun
Wead, William B
description We have previously shown that protein kinase C (PKC)-epsilon, nuclear factor (NF)-kappaB, and mitogen-activated protein kinases (MAPKs) are essential signaling elements in ischemic preconditioning. In the present study, we examined whether activation of PKCepsilon affects the activation of NF-kappaB in cardiac myocytes and whether MAPKs are mediators of this signaling event.
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ispartof American journal of physiology. Heart and circulatory physiology, 2000-10, Vol.48 (4), p.H1679
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1522-1539
language eng
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source American Physiological Society Free
subjects Circulatory system
Proteins
Rabbits
title PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes
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