Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle

Proteolysis of the capillary basement membrane is a hallmark of inflammation-mediated angiogenesis, but it is undetermined whether proteolysis plays a critical role in the process of activity-induced angiogenesis. Matrix metalloproteinases (MMPs) constitute the major class of proteases responsible f...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-10, Vol.48 (4), p.H1540-H1547
Main Authors: HAAS, T. L, MILKIEWICZ, M, DAVIS, S. J, ZHOU, A. L, EGGINTON, S, BROWN, M. D, MADRI, J. A, HUDLICKA, O
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood vessels
Fundamental and applied biological sciences. Psychology
Membranes
Muscular system
Proteins
Rodents
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:Proteolysis of the capillary basement membrane is a hallmark of inflammation-mediated angiogenesis, but it is undetermined whether proteolysis plays a critical role in the process of activity-induced angiogenesis. Matrix metalloproteinases (MMPs) constitute the major class of proteases responsible for degradation of basement membrane proteins.
ISSN:0363-6135
1522-1539