[Ca2+]i signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS

Vascular resistance and arterial pressure are reduced during normal pregnancy, buyt dangerously elevated during pregnancy-induced hypertension (PIH), and changes in nitric oxide (NO) synthesis have been hypothesized as one potential cause. In support of this hypothesis, chronic inhibition of NO synt...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001, Vol.49 (1), p.R87-R99
Main Authors: MURPHY, Jason G, FLEMING, John B, COCKRELL, Kathy L, GRANGER, Joey P, KHALIL, Raouf A
Format: Article
Language:English
Subjects:
Animal reproduction
Biological and medical sciences
Blood vessels and receptors
Calcium
Cells
Fundamental and applied biological sciences. Psychology
Hypertension
Kidneys
Muscular system
Rodents
Vertebrates: cardiovascular system
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Summary:Vascular resistance and arterial pressure are reduced during normal pregnancy, buyt dangerously elevated during pregnancy-induced hypertension (PIH), and changes in nitric oxide (NO) synthesis have been hypothesized as one potential cause. In support of this hypothesis, chronic inhibition of NO synthesis in pregnant rats has been shown to cause significant increases in renal vascular resistance and hypertension; however, the cellular mechanisms involved are unclear.
ISSN:0363-6119
1522-1490