A role for NMDA receptors in posthypoxic frequency decline in the rat

Posthypoxic frequency decline (PHFD) refers to the undershoot in respiratory frequency that follows brief hypoxic exposures. Lateral pontine neurons are required for PHFD. The neurotransmitters involved in the circuit that activate and/or are released by these pontine neurons regulating PHFD are unk...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-06, Vol.43 (6), p.R1546-R1555
Main Authors: COLES, S. K, ERNSBERGER, P, DICK, T. E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain
Fundamental and applied biological sciences. Psychology
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Neurons
Respiratory system
Rodents
Vertebrates: nervous system and sense organs
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Summary:Posthypoxic frequency decline (PHFD) refers to the undershoot in respiratory frequency that follows brief hypoxic exposures. Lateral pontine neurons are required for PHFD. The neurotransmitters involved in the circuit that activate and/or are released by these pontine neurons regulating PHFD are unknown. We hypothesized that N-methyl-D-aspartate (NMDA) receptors are required for PHFD, because of the similarity in respiratory pattern after blocking lateral pontine activity or NMDA receptors.
ISSN:0363-6119
1522-1490