HPA-axis responses during experimental colitis in the rat

We investigated the responses of the hypothalamicpituitary-adrenal (HPA) axis during experimental colitis induced by intracolonic administration of 2,4,6-trinitrobenzene-sulfonic acid in the rat. On days 3 and 7 after induction of colitis, the corticotropin-releasing hormone (CRH) mRNA level in the...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-05, Vol.51 (5), p.R1348-R1355
Main Authors: KOJIMA, Kensaku, NARUSE, Yoshihisa, IIJIMA, Norio, WAKABAYASHI, Naoki, MITSUFUJI, Shoji, IBATA, Yasuhiko, TANAKA, Masaki
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bowel disease
Colon
Gastroenterology. Liver. Pancreas. Abdomen
Hormones
Medical sciences
Other diseases. Semiology
Rodents
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:We investigated the responses of the hypothalamicpituitary-adrenal (HPA) axis during experimental colitis induced by intracolonic administration of 2,4,6-trinitrobenzene-sulfonic acid in the rat. On days 3 and 7 after induction of colitis, the corticotropin-releasing hormone (CRH) mRNA level in the parvocellular paraventricular nucleus (pPVN) of the hypothalamus was reduced, the plasma ACTH level remained at the basal level, and the plasma corticosterone (Cort) level was high.
ISSN:0363-6119
1522-1490