Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid

The effects of blockade of the reninangiotensin system on the renal metabolism of arachidonic acid (AA) were examined. The production of 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) by renal cortical microsomes increased in rats treated with captopril by 59 and 24%...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-03, Vol.49 (3), p.R822-R830
Main Authors: ITO, Osamu, OMATA, Ken, ITO, Sadayoshi, HOAGLAND, Kimberly M, ROMAN, Richard J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Enzymes
Fundamental and applied biological sciences. Psychology
Kidneys
Metabolism
Vertebrates: urinary system
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Summary:The effects of blockade of the reninangiotensin system on the renal metabolism of arachidonic acid (AA) were examined. The production of 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) by renal cortical microsomes increased in rats treated with captopril by 59 and 24% and by 90 and 58% in rats treated with enalapril.
ISSN:0363-6119
1522-1490