Volume expansion during NOS substrate donation with L-arginine: regulatory offsetting of renal response?

The responses to infusion of nitrix oxide synthase substrate (L-arginine 3 mg-kg(-1)-min(-1)) and to slow volume expansion (saline 35 ml/kg for 90 min) alone and in combination were investigated in separate experiments. L-Arginine left blood pressure and plasma ANG II unaffected but decreased heart...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-04, Vol.51 (4), p.R1149-R1155
Main Authors: ANDERSEN, Jens Lundbaek, SANDGAARD, Niels C. F, BIE, Peter
Format: Article
Language:English
Subjects:
Biological and medical sciences
Enzymes
Fundamental and applied biological sciences. Psychology
Kidneys
Sodium
Vertebrates: urinary system
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Summary:The responses to infusion of nitrix oxide synthase substrate (L-arginine 3 mg-kg(-1)-min(-1)) and to slow volume expansion (saline 35 ml/kg for 90 min) alone and in combination were investigated in separate experiments. L-Arginine left blood pressure and plasma ANG II unaffected but decreased heart rate (6 +/- 2 beats/min) and urine osmolality, increased glomerular filtration rate (GFR) transiently, and caused sustained increases in sodium excretion (fourfold) and urine flow (0.2 +/- 0.0 to 0.7 +/- 0.1 ml/min).
ISSN:0363-6119
1522-1490