Brain angiotensin receptors and sympathoadrenal regulation during insulin-induced hypoglycemia

Simultaneous blockade of systemic AT1 and AT2 receptors or converting enzyme inhibition (CEI) attenuates the hypoglycemia-induced reflex increase of epinephrine (Epi). To examine the role of brain AT1 and AT2 receptors in the reflec regulation of Epi release, we measured catecholamines, hemodynamics...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-04, Vol.49 (4), p.R1162-R1168
Main Authors: WORCK, René H, STAAHLTOFT, Dennis, JONASSEN, Thomas E. N, FRANDSEN, Erik, IBSEN, Hans, PETERSEN, Jørgen S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood pressure
Brain
Enzymes
Fundamental and applied biological sciences. Psychology
Hypoglycemia
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Reflexes
Vertebrates: nervous system and sense organs
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Summary:Simultaneous blockade of systemic AT1 and AT2 receptors or converting enzyme inhibition (CEI) attenuates the hypoglycemia-induced reflex increase of epinephrine (Epi). To examine the role of brain AT1 and AT2 receptors in the reflec regulation of Epi release, we measured catecholamines, hemodynamics, and renin during insulin-induced hypoglycemia in conscious rats pretreated intracerebroventricularly with losartan, PD-123319, losartan and PD-123319, or vehicle.
ISSN:0363-6119
1522-1490