EAA receptors in the dorsomedial hypothalamic area mediate the cardiovascular response to activation of the amygdala

The role of excitatory amino acid (EAA) receptors in the dorsomedial hypothalamus (DMH) in mediating the cardiovascular response to activation of the basolateral amygdala (BLA) was examined using conscious rats. Microinjection of the nonselective EAA receptor antagonist kynurenic acid (0.1-10 nmol)...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-08, Vol.44 (2), p.R624-R631
Main Authors: SOLTIS, R. P, COOK, J. C, GREGG, A. E, STRATTON, J. M, FLICKINGER, K. A
Format: Article
Language:English
Subjects:
Amino acids
Biological and medical sciences
Brain
Fundamental and applied biological sciences. Psychology
Heart
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Vertebrates: nervous system and sense organs
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Summary:The role of excitatory amino acid (EAA) receptors in the dorsomedial hypothalamus (DMH) in mediating the cardiovascular response to activation of the basolateral amygdala (BLA) was examined using conscious rats. Microinjection of the nonselective EAA receptor antagonist kynurenic acid (0.1-10 nmol) into the DMH blocked or reversed the increases in heart rate and arterial pressure resulting from injection of the GABAA receptor antagonists bicuculline methiodide (BMI; 100 pmol) and picrotoxin (100 pmol) into the BLA.
ISSN:0363-6119
1522-1490