Vasodilation elicited by liposomal VIP is unimpeded by anti-VIP antibody in hamster cheek pouch

The purpose of this study was to determine whether a monoclonal anti-vasoactive intestinal peptide (VIP) antibody, which binds VIP with high affinity and specificity and catalyzes cleavage of the peptide in vitro, attenuates VIP vasorelaxation in vivo and, if so, whether insertion of VIP on the surf...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-07, Vol.44 (1), p.R56-R62
Main Authors: IKEZAKI, H, PAUL, S, ALKAN-ÖNYÜKSEL, H, PATEL, M, GAO, X.-P, RUBINSTEIN, I
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Immune system
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Peptides
Vertebrates: nervous system and sense organs
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to determine whether a monoclonal anti-vasoactive intestinal peptide (VIP) antibody, which binds VIP with high affinity and specificity and catalyzes cleavage of the peptide in vitro, attenuates VIP vasorelaxation in vivo and, if so, whether insertion of VIP on the surface of sterically stabilized liposomes (SSL), which protects the peptide from trypsin- and plasma-catalyzed cleavage in vitro, curtails this response.
ISSN:0363-6119
1522-1490