Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting

The ob gene product leptin is known to produce anorexia, and loss of body fat when chronically administered to both lean and genetically obese mice. The current study was undertaken to examine whether administration of recombinant leptin in quantities sufficient to produce decreases in food intake a...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-06, Vol.43 (6), p.R1518-R1525
Main Authors: KAIBARA, A, MOSHYEDI, A, AUFFENBERG, T, ABOUHAMZE, A, COPELAND, E. M, KALRA, S, MOLDAWER, L. L
Format: Article
Language:English
Subjects:
Anatomy & physiology
Anorexia
Biological and medical sciences
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Liver
Proteins
Tumors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The ob gene product leptin is known to produce anorexia, and loss of body fat when chronically administered to both lean and genetically obese mice. The current study was undertaken to examine whether administration of recombinant leptin in quantities sufficient to produce decreases in food intake and body weight and alterations in body composition would elicit either an hepatic acute phase protein response or preferential loss of carcass lean tissue.
ISSN:0363-6119
1522-1490