Effects of L-NAME on cerebral metabolic, vasopressin, oxytocin, and blood pressure responses in hemorrhaged rats

NG-nitro-L-arginine methyl ester (L-NAME; 250,mug/5,mul), an inhibitor of NO synthase, or the vehicle artificial cerebrospinal fluid (aCSF; 5 mul) was administered intracerebroventricularly to conscious rats hemorrhaged (0.7 ml/min) to a 20% volume depletion. Hypotension was maximal 5 min after hemo...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-04, Vol.43 (4), p.R1070-R1077
Main Authors: KADEKARO, M, TERRELL, M. L, HANWU LIU, GESTL, S, VUONG BUI, SUMMY-LONG, J. Y
Format: Article
Language:English
Subjects:
Biochemistry
Biological and medical sciences
Blood pressure
Body fluids
Brain
Enzymes
Fundamental and applied biological sciences. Psychology
Hemorrhage
Metabolism
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Vertebrates: nervous system and sense organs
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Summary:NG-nitro-L-arginine methyl ester (L-NAME; 250,mug/5,mul), an inhibitor of NO synthase, or the vehicle artificial cerebrospinal fluid (aCSF; 5 mul) was administered intracerebroventricularly to conscious rats hemorrhaged (0.7 ml/min) to a 20% volume depletion. Hypotension was maximal 5 min after hemorrhage ended, with compensatory recovery to basal levels 20 min later, regardless of drug treatment.
ISSN:0363-6119
1522-1490