Hyperglycemia modulates angiotensinogen gene expression

Elevated plasma angiotensinogen (AGT) levels have been demonstrated in insulin-resistant states such as obesity and type 2 diabetes mellitus (DM2), conditions that are directly correlated to hypertension. We examined whether hyperinsulinemia or hyperglycemia may modulate fat and liver AGT gen expres...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-09, Vol.50 (3), p.R795-R802
Main Authors: GABRIELY, Ilan, XIAO MAN YANG, CASES, Jane A, XIAO HUI MA, ROSSETTI, Luciano, BARZILAI, Nir
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body fat
Genes
Insulin
Liver
Medical sciences
Metabolic diseases
Obesity
Tissues
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Summary:Elevated plasma angiotensinogen (AGT) levels have been demonstrated in insulin-resistant states such as obesity and type 2 diabetes mellitus (DM2), conditions that are directly correlated to hypertension. We examined whether hyperinsulinemia or hyperglycemia may modulate fat and liver AGT gen expression and whether obesity and insulin resistance are associated with abnormal AGT regulation.
ISSN:0363-6119
1522-1490