Hyperglycemia modulates angiotensinogen gene expression

Elevated plasma angiotensinogen (AGT) levels have been demonstrated in insulin-resistant states such as obesity and type 2 diabetes mellitus (DM2), conditions that are directly correlated to hypertension. We examined whether hyperinsulinemia or hyperglycemia may modulate fat and liver AGT gen expres...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-09, Vol.50 (3), p.R795-R802
Main Authors: GABRIELY, Ilan, XIAO MAN YANG, CASES, Jane A, XIAO HUI MA, ROSSETTI, Luciano, BARZILAI, Nir
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body fat
Genes
Insulin
Liver
Medical sciences
Metabolic diseases
Obesity
Tissues
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container_end_page R802
container_issue 3
container_start_page R795
container_title American journal of physiology. Regulatory, integrative and comparative physiology
container_volume 50
creator GABRIELY, Ilan
XIAO MAN YANG
CASES, Jane A
XIAO HUI MA
ROSSETTI, Luciano
BARZILAI, Nir
description Elevated plasma angiotensinogen (AGT) levels have been demonstrated in insulin-resistant states such as obesity and type 2 diabetes mellitus (DM2), conditions that are directly correlated to hypertension. We examined whether hyperinsulinemia or hyperglycemia may modulate fat and liver AGT gen expression and whether obesity and insulin resistance are associated with abnormal AGT regulation.
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ispartof American journal of physiology. Regulatory, integrative and comparative physiology, 2001-09, Vol.50 (3), p.R795-R802
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1522-1490
language eng
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source American Physiological Society Free
subjects Biological and medical sciences
Body fat
Genes
Insulin
Liver
Medical sciences
Metabolic diseases
Obesity
Tissues
title Hyperglycemia modulates angiotensinogen gene expression
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