Higher skeletal muscle protein synthesis and lower breakdown after chemotherapy in cachectic mice

The influence of cancer cachexia and chemotherapy and subsequent recovery of skeletal muscle protein mass and turnover was investigated in mice. Cancer cachexia was induced using colon 26 adenocarcinoma, which is characteristic of the human condition, and can be cured with 100% efficacy using an exp...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-07, Vol.50 (1), p.R133-R139
Main Authors: SAMUELS, S. E, KNOWLES, A. L, TILIGNAC, T, DEBITON, E, MADELMONT, J. C, ATTAIX, D
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Cancer
Chemotherapy
General aspects
Medical sciences
Muscular system
Pharmacology. Drug treatments
Proteins
Rodents
Skeletal system
Tumors
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Summary:The influence of cancer cachexia and chemotherapy and subsequent recovery of skeletal muscle protein mass and turnover was investigated in mice. Cancer cachexia was induced using colon 26 adenocarcinoma, which is characteristic of the human condition, and can be cured with 100% efficacy using an experimental nitrosourea, cystemustine (C6H12CIN3O4S).
ISSN:0363-6119
1522-1490