Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats : reversal by insulin

Evidence for regulation of circulating leptin by insulin is conflicting. Diabetes was induced in rats with streptozotocin (STZ; 40 mg-kg-1-day-1 x 2 days) to examine the effect of insulin-deficient diabetes and insulin treatment on circulating leptin. After 12 wk, plasma leptin concentrations in unt...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-05, Vol.43 (5), p.R1482-R1491
Main Authors: HAVEL, P. J, URIU-HARE, J. Y, LIU, T, STANHOPE, K. L, STERN, J. S, KEEN, C. L, AHREN, B
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Insulin
Medical sciences
Peptides
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Summary:Evidence for regulation of circulating leptin by insulin is conflicting. Diabetes was induced in rats with streptozotocin (STZ; 40 mg-kg-1-day-1 x 2 days) to examine the effect of insulin-deficient diabetes and insulin treatment on circulating leptin. After 12 wk, plasma leptin concentrations in untreated rats were all
ISSN:0363-6119
1522-1490