Loading…
Different Effects of 5-HT1 and 5-HT2 Receptor Agonists on Excitability Modulation of Motoneurons in Frog Spinal Cord
Effects of 5-HT 1 and 5-HT 2 receptor agonists and antagonists on membrane properties of motoneurons in the isolated lumbar segment of the frog spinal cord were investigated using intracellular recordings. Application of a 5-HT 2A,B,C receptor agonist α-Me-5-HT evoked depolarization of the motoneuro...
Saved in:
| Published in: | Journal of evolutionary biochemistry and physiology 2019-07, Vol.55 (4), p.284-292 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c246t-f72d4c7e0112448a3ad1adc22a01743496f4df6d3867ed1fb32604d8592c276b3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c246t-f72d4c7e0112448a3ad1adc22a01743496f4df6d3867ed1fb32604d8592c276b3 |
| container_end_page | 292 |
| container_issue | 4 |
| container_start_page | 284 |
| container_title | Journal of evolutionary biochemistry and physiology |
| container_volume | 55 |
| creator | Kalinina, N. A. Zaitsev, A. V. Vesselkin, N. P. |
| description | Effects of 5-HT
1
and 5-HT
2
receptor agonists and antagonists on membrane properties of motoneurons in the isolated lumbar segment of the frog spinal cord were investigated using intracellular recordings. Application of a 5-HT
2A,B,C
receptor agonist α-Me-5-HT evoked depolarization of the motoneuronal membrane. The co-application of α-Me-5-HT and a specific 5-HT
2B
receptor antagonist SB 206553 did not result in depolarization. α-Me-5-HT reduced the amplitude of medium afterhyperpolarization and increased the number of antidromic action potentials (APs). The application of an antagonist SB 206553 abolished these effects. A 5-HT
1A/7
receptor agonist 8-OH-DPAT had a time-dependent effect on the number of antidromic APs, evoking an initial short-term excitation followed by an inhibition. The data obtained in our experiments indicate the presence of 5-HT
1A/7
and 5-HT
2B,C
receptors on the postsynaptic membrane of motoneurons. We suggest a possible co-modulation of the accommodative properties of motoneurons by the two types of serotonin receptors, 5-HT
2B,C
and 5-HT
1A
. |
| doi_str_mv | 10.1134/S0022093019040045 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2298770967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2298770967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c246t-f72d4c7e0112448a3ad1adc22a01743496f4df6d3867ed1fb32604d8592c276b3</originalsourceid><addsrcrecordid>eNp1kEtLAzEUhYMoWKs_wF3A9ejNo_NYltpaoUWwdT2keZSUMRmTDNh_74wVXIire7jnO4fLReiWwD0hjD9sACiFigGpgAPwyRkakRzKjFGg52g02NngX6KrGA8AUJWcj1B6tMbooF3C817IFLE3eJIttwQLp74Vxa9a6jb5gKd772wcIIfnn9ImsbONTUe89qprRLL9vs-vffJOd8G7iK3Di-D3eNNaJxo880FdowsjmqhvfuYYvS3m29kyW708Pc-mq0xSnqfMFFRxWWgghHJeCiYUEUpSKoAUnPEqN1yZXLEyL7QiZsdoDlyVk4pKWuQ7NkZ3p942-I9Ox1QffBf6K2JNaVUWBVR50VPkRMngYwza1G2w7yIcawL18Nz6z3P7DD1lYs-6vQ6_zf-HvgAZZHmQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2298770967</pqid></control><display><type>article</type><title>Different Effects of 5-HT1 and 5-HT2 Receptor Agonists on Excitability Modulation of Motoneurons in Frog Spinal Cord</title><source>Springer Link</source><creator>Kalinina, N. A. ; Zaitsev, A. V. ; Vesselkin, N. P.</creator><creatorcontrib>Kalinina, N. A. ; Zaitsev, A. V. ; Vesselkin, N. P.</creatorcontrib><description>Effects of 5-HT
1
and 5-HT
2
receptor agonists and antagonists on membrane properties of motoneurons in the isolated lumbar segment of the frog spinal cord were investigated using intracellular recordings. Application of a 5-HT
2A,B,C
receptor agonist α-Me-5-HT evoked depolarization of the motoneuronal membrane. The co-application of α-Me-5-HT and a specific 5-HT
2B
receptor antagonist SB 206553 did not result in depolarization. α-Me-5-HT reduced the amplitude of medium afterhyperpolarization and increased the number of antidromic action potentials (APs). The application of an antagonist SB 206553 abolished these effects. A 5-HT
1A/7
receptor agonist 8-OH-DPAT had a time-dependent effect on the number of antidromic APs, evoking an initial short-term excitation followed by an inhibition. The data obtained in our experiments indicate the presence of 5-HT
1A/7
and 5-HT
2B,C
receptors on the postsynaptic membrane of motoneurons. We suggest a possible co-modulation of the accommodative properties of motoneurons by the two types of serotonin receptors, 5-HT
2B,C
and 5-HT
1A
.</description><identifier>ISSN: 0022-0930</identifier><identifier>EISSN: 1608-3202</identifier><identifier>DOI: 10.1134/S0022093019040045</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>8-Hydroxy-2-(di-n-propylamino)tetralin ; Afterhyperpolarization ; Agonists ; Animal Physiology ; Biochemistry ; Biomedical and Life Sciences ; Comparative and Ontogenic Biochemistry ; Depolarization ; Evolutionary Biology ; Excitability ; Life Sciences ; Membrane potential ; Motor neurons ; Receptor mechanisms ; Serotonin receptors ; Serotonin S1 receptors ; Serotonin S2 receptors ; Spinal cord</subject><ispartof>Journal of evolutionary biochemistry and physiology, 2019-07, Vol.55 (4), p.284-292</ispartof><rights>Pleiades Publishing, Ltd. 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c246t-f72d4c7e0112448a3ad1adc22a01743496f4df6d3867ed1fb32604d8592c276b3</citedby><cites>FETCH-LOGICAL-c246t-f72d4c7e0112448a3ad1adc22a01743496f4df6d3867ed1fb32604d8592c276b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kalinina, N. A.</creatorcontrib><creatorcontrib>Zaitsev, A. V.</creatorcontrib><creatorcontrib>Vesselkin, N. P.</creatorcontrib><title>Different Effects of 5-HT1 and 5-HT2 Receptor Agonists on Excitability Modulation of Motoneurons in Frog Spinal Cord</title><title>Journal of evolutionary biochemistry and physiology</title><addtitle>J Evol Biochem Phys</addtitle><description>Effects of 5-HT
1
and 5-HT
2
receptor agonists and antagonists on membrane properties of motoneurons in the isolated lumbar segment of the frog spinal cord were investigated using intracellular recordings. Application of a 5-HT
2A,B,C
receptor agonist α-Me-5-HT evoked depolarization of the motoneuronal membrane. The co-application of α-Me-5-HT and a specific 5-HT
2B
receptor antagonist SB 206553 did not result in depolarization. α-Me-5-HT reduced the amplitude of medium afterhyperpolarization and increased the number of antidromic action potentials (APs). The application of an antagonist SB 206553 abolished these effects. A 5-HT
1A/7
receptor agonist 8-OH-DPAT had a time-dependent effect on the number of antidromic APs, evoking an initial short-term excitation followed by an inhibition. The data obtained in our experiments indicate the presence of 5-HT
1A/7
and 5-HT
2B,C
receptors on the postsynaptic membrane of motoneurons. We suggest a possible co-modulation of the accommodative properties of motoneurons by the two types of serotonin receptors, 5-HT
2B,C
and 5-HT
1A
.</description><subject>8-Hydroxy-2-(di-n-propylamino)tetralin</subject><subject>Afterhyperpolarization</subject><subject>Agonists</subject><subject>Animal Physiology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Comparative and Ontogenic Biochemistry</subject><subject>Depolarization</subject><subject>Evolutionary Biology</subject><subject>Excitability</subject><subject>Life Sciences</subject><subject>Membrane potential</subject><subject>Motor neurons</subject><subject>Receptor mechanisms</subject><subject>Serotonin receptors</subject><subject>Serotonin S1 receptors</subject><subject>Serotonin S2 receptors</subject><subject>Spinal cord</subject><issn>0022-0930</issn><issn>1608-3202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLAzEUhYMoWKs_wF3A9ejNo_NYltpaoUWwdT2keZSUMRmTDNh_74wVXIire7jnO4fLReiWwD0hjD9sACiFigGpgAPwyRkakRzKjFGg52g02NngX6KrGA8AUJWcj1B6tMbooF3C817IFLE3eJIttwQLp74Vxa9a6jb5gKd772wcIIfnn9ImsbONTUe89qprRLL9vs-vffJOd8G7iK3Di-D3eNNaJxo880FdowsjmqhvfuYYvS3m29kyW708Pc-mq0xSnqfMFFRxWWgghHJeCiYUEUpSKoAUnPEqN1yZXLEyL7QiZsdoDlyVk4pKWuQ7NkZ3p942-I9Ox1QffBf6K2JNaVUWBVR50VPkRMngYwza1G2w7yIcawL18Nz6z3P7DD1lYs-6vQ6_zf-HvgAZZHmQ</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Kalinina, N. A.</creator><creator>Zaitsev, A. V.</creator><creator>Vesselkin, N. P.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>20190701</creationdate><title>Different Effects of 5-HT1 and 5-HT2 Receptor Agonists on Excitability Modulation of Motoneurons in Frog Spinal Cord</title><author>Kalinina, N. A. ; Zaitsev, A. V. ; Vesselkin, N. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-f72d4c7e0112448a3ad1adc22a01743496f4df6d3867ed1fb32604d8592c276b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>8-Hydroxy-2-(di-n-propylamino)tetralin</topic><topic>Afterhyperpolarization</topic><topic>Agonists</topic><topic>Animal Physiology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Comparative and Ontogenic Biochemistry</topic><topic>Depolarization</topic><topic>Evolutionary Biology</topic><topic>Excitability</topic><topic>Life Sciences</topic><topic>Membrane potential</topic><topic>Motor neurons</topic><topic>Receptor mechanisms</topic><topic>Serotonin receptors</topic><topic>Serotonin S1 receptors</topic><topic>Serotonin S2 receptors</topic><topic>Spinal cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalinina, N. A.</creatorcontrib><creatorcontrib>Zaitsev, A. V.</creatorcontrib><creatorcontrib>Vesselkin, N. P.</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of evolutionary biochemistry and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalinina, N. A.</au><au>Zaitsev, A. V.</au><au>Vesselkin, N. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different Effects of 5-HT1 and 5-HT2 Receptor Agonists on Excitability Modulation of Motoneurons in Frog Spinal Cord</atitle><jtitle>Journal of evolutionary biochemistry and physiology</jtitle><stitle>J Evol Biochem Phys</stitle><date>2019-07-01</date><risdate>2019</risdate><volume>55</volume><issue>4</issue><spage>284</spage><epage>292</epage><pages>284-292</pages><issn>0022-0930</issn><eissn>1608-3202</eissn><abstract>Effects of 5-HT
1
and 5-HT
2
receptor agonists and antagonists on membrane properties of motoneurons in the isolated lumbar segment of the frog spinal cord were investigated using intracellular recordings. Application of a 5-HT
2A,B,C
receptor agonist α-Me-5-HT evoked depolarization of the motoneuronal membrane. The co-application of α-Me-5-HT and a specific 5-HT
2B
receptor antagonist SB 206553 did not result in depolarization. α-Me-5-HT reduced the amplitude of medium afterhyperpolarization and increased the number of antidromic action potentials (APs). The application of an antagonist SB 206553 abolished these effects. A 5-HT
1A/7
receptor agonist 8-OH-DPAT had a time-dependent effect on the number of antidromic APs, evoking an initial short-term excitation followed by an inhibition. The data obtained in our experiments indicate the presence of 5-HT
1A/7
and 5-HT
2B,C
receptors on the postsynaptic membrane of motoneurons. We suggest a possible co-modulation of the accommodative properties of motoneurons by the two types of serotonin receptors, 5-HT
2B,C
and 5-HT
1A
.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0022093019040045</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-0930 |
| ispartof | Journal of evolutionary biochemistry and physiology, 2019-07, Vol.55 (4), p.284-292 |
| issn | 0022-0930 1608-3202 |
| language | eng |
| recordid | cdi_proquest_journals_2298770967 |
| source | Springer Link |
| subjects | 8-Hydroxy-2-(di-n-propylamino)tetralin Afterhyperpolarization Agonists Animal Physiology Biochemistry Biomedical and Life Sciences Comparative and Ontogenic Biochemistry Depolarization Evolutionary Biology Excitability Life Sciences Membrane potential Motor neurons Receptor mechanisms Serotonin receptors Serotonin S1 receptors Serotonin S2 receptors Spinal cord |
| title | Different Effects of 5-HT1 and 5-HT2 Receptor Agonists on Excitability Modulation of Motoneurons in Frog Spinal Cord |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-24T02%3A21%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20Effects%20of%205-HT1%20and%205-HT2%20Receptor%20Agonists%20on%20Excitability%20Modulation%20of%20Motoneurons%20in%20Frog%20Spinal%20Cord&rft.jtitle=Journal%20of%20evolutionary%20biochemistry%20and%20physiology&rft.au=Kalinina,%20N.%20A.&rft.date=2019-07-01&rft.volume=55&rft.issue=4&rft.spage=284&rft.epage=292&rft.pages=284-292&rft.issn=0022-0930&rft.eissn=1608-3202&rft_id=info:doi/10.1134/S0022093019040045&rft_dat=%3Cproquest_cross%3E2298770967%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c246t-f72d4c7e0112448a3ad1adc22a01743496f4df6d3867ed1fb32604d8592c276b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2298770967&rft_id=info:pmid/&rfr_iscdi=true |