ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population

A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had nor...

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Published in:International journal of diabetes in developing countries 2018-10, Vol.38 (4), p.403-408
Main Authors: Liu, Na, Yang, Guihua, Hu, Mei, Han, Jing, Cai, Yuyu, Hu, Zhiying, Jia, Chundi, Zhang, Man
Format: Article
Language:English
Subjects:
Alleles
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Family Medicine
Fasting
Gene polymorphism
General Practice
Glucose
Health Administration
Insulin
Insulin resistance
Laboratory testing
Medicine
Medicine & Public Health
Original Article
Single-nucleotide polymorphism
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Summary:A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had normal FPG levels. This study included 2038 subjects among the non-diabetic Chinese Han population. The ADIPOR2 polymorphisms were genotyped by the TaqMan method. For the analysis, participants were divided into low-normal FPG group (FPG  FPG ≥ 4.88 mmol/L). We identified five single nucleotide polymorphisms (SNPs) of ADIPOR2 gene: rs10773989, rs2370055, rs9300298, rs10773983, and rs13611594. There was no significant difference in FPG levels between different genotypes of rs10773989, rs2370055, rs9300298, and rs13611594. Our data showed a significant association of rs10773983 with higher FPG levels, fasting insulin levels, and homeostatic model assessment of insulin resistance (HOMA-IR) in A-allele carriers ( p  = 0.006, p  
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-018-0620-7