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ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population
A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had nor...
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| Published in: | International journal of diabetes in developing countries 2018-10, Vol.38 (4), p.403-408 |
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| container_end_page | 408 |
| container_issue | 4 |
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| container_title | International journal of diabetes in developing countries |
| container_volume | 38 |
| creator | Liu, Na Yang, Guihua Hu, Mei Han, Jing Cai, Yuyu Hu, Zhiying Jia, Chundi Zhang, Man |
| description | A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had normal FPG levels. This study included 2038 subjects among the non-diabetic Chinese Han population. The ADIPOR2 polymorphisms were genotyped by the TaqMan method. For the analysis, participants were divided into low-normal FPG group (FPG FPG ≥ 4.88 mmol/L). We identified five single nucleotide polymorphisms (SNPs) of ADIPOR2 gene: rs10773989, rs2370055, rs9300298, rs10773983, and rs13611594. There was no significant difference in FPG levels between different genotypes of rs10773989, rs2370055, rs9300298, and rs13611594. Our data showed a significant association of rs10773983 with higher FPG levels, fasting insulin levels, and homeostatic model assessment of insulin resistance (HOMA-IR) in A-allele carriers (
p
= 0.006,
p
|
| doi_str_mv | 10.1007/s13410-018-0620-7 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2299478367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2299478367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-a7ce5e0ab39e54ee02c3a61cd9829fd6d876f941dcf1b09c9a1085a71cc43b353</originalsourceid><addsrcrecordid>eNp1kM1KxDAYRYMoOI4-gLuA62h-2qZZDuPPDAgjouuQpmmboSY1SUd8eztUcOXqW9x77gcHgGuCbwnG_C4SlhGMMCkRLihG_AQsiBAlYiWjp2CBBWeICYbPwUWMe4zznBZsAZrV_fZl90rhQQWrXII2QhWj11YlU8MvmzrY2bYzATYqJuta2Paj9tHA3hxMD62DzjtUW1WZZDVcd9aZKd0oBwc_jL1K1rtLcNaoPpqr37sE748Pb-sNet49bderZ6RpUSakuDa5wapiwuSZMZhqpgqia1FS0dRFXfKiERmpdUMqLLRQBJe54kTrjFUsZ0twM-8OwX-OJia592Nw00tJqRAZL1nBpxaZWzr4GINp5BDshwrfkmB51ClnnXLSKY865ZGhMxOnrmtN-Fv-H_oBPRx4UA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2299478367</pqid></control><display><type>article</type><title>ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population</title><source>Springer Link</source><creator>Liu, Na ; Yang, Guihua ; Hu, Mei ; Han, Jing ; Cai, Yuyu ; Hu, Zhiying ; Jia, Chundi ; Zhang, Man</creator><creatorcontrib>Liu, Na ; Yang, Guihua ; Hu, Mei ; Han, Jing ; Cai, Yuyu ; Hu, Zhiying ; Jia, Chundi ; Zhang, Man</creatorcontrib><description>A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had normal FPG levels. This study included 2038 subjects among the non-diabetic Chinese Han population. The ADIPOR2 polymorphisms were genotyped by the TaqMan method. For the analysis, participants were divided into low-normal FPG group (FPG < 4.88 mmol/L) and high-normal FPG group (6.1 mmol/L > FPG ≥ 4.88 mmol/L). We identified five single nucleotide polymorphisms (SNPs) of ADIPOR2 gene: rs10773989, rs2370055, rs9300298, rs10773983, and rs13611594. There was no significant difference in FPG levels between different genotypes of rs10773989, rs2370055, rs9300298, and rs13611594. Our data showed a significant association of rs10773983 with higher FPG levels, fasting insulin levels, and homeostatic model assessment of insulin resistance (HOMA-IR) in A-allele carriers (
p
= 0.006,
p
< 0.001, and
p
< 0.001, respectively). The subjects in high FPG group had higher median fasting insulin level (9.25 vs 8.16 μIU/mL,
p
= 0.003) and higher HOMA-IR (2.21 vs 1.58,
p
< 0.001) than those in normal FPG group. Subjects with the A-allele of rs10773983 compared to subjects with G-allele had 1.222-fold higher risk for high-normal FPG (OR = 1.222, 95%CI = 1.010–1.478,
p
= 0.039). Our findings suggest that ADIPOR2 rs10773983 polymorphism may be associated with an increased risk of high-normal FPG among non-diabetic Chinese Han subjects who have normal FPG levels.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.1007/s13410-018-0620-7</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Alleles ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Family Medicine ; Fasting ; Gene polymorphism ; General Practice ; Glucose ; Health Administration ; Insulin ; Insulin resistance ; Laboratory testing ; Medicine ; Medicine & Public Health ; Original Article ; Single-nucleotide polymorphism</subject><ispartof>International journal of diabetes in developing countries, 2018-10, Vol.38 (4), p.403-408</ispartof><rights>Research Society for Study of Diabetes in India 2018</rights><rights>Copyright Springer Nature B.V. 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-a7ce5e0ab39e54ee02c3a61cd9829fd6d876f941dcf1b09c9a1085a71cc43b353</cites><orcidid>0000-0001-5166-6804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Yang, Guihua</creatorcontrib><creatorcontrib>Hu, Mei</creatorcontrib><creatorcontrib>Han, Jing</creatorcontrib><creatorcontrib>Cai, Yuyu</creatorcontrib><creatorcontrib>Hu, Zhiying</creatorcontrib><creatorcontrib>Jia, Chundi</creatorcontrib><creatorcontrib>Zhang, Man</creatorcontrib><title>ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had normal FPG levels. This study included 2038 subjects among the non-diabetic Chinese Han population. The ADIPOR2 polymorphisms were genotyped by the TaqMan method. For the analysis, participants were divided into low-normal FPG group (FPG < 4.88 mmol/L) and high-normal FPG group (6.1 mmol/L > FPG ≥ 4.88 mmol/L). We identified five single nucleotide polymorphisms (SNPs) of ADIPOR2 gene: rs10773989, rs2370055, rs9300298, rs10773983, and rs13611594. There was no significant difference in FPG levels between different genotypes of rs10773989, rs2370055, rs9300298, and rs13611594. Our data showed a significant association of rs10773983 with higher FPG levels, fasting insulin levels, and homeostatic model assessment of insulin resistance (HOMA-IR) in A-allele carriers (
p
= 0.006,
p
< 0.001, and
p
< 0.001, respectively). The subjects in high FPG group had higher median fasting insulin level (9.25 vs 8.16 μIU/mL,
p
= 0.003) and higher HOMA-IR (2.21 vs 1.58,
p
< 0.001) than those in normal FPG group. Subjects with the A-allele of rs10773983 compared to subjects with G-allele had 1.222-fold higher risk for high-normal FPG (OR = 1.222, 95%CI = 1.010–1.478,
p
= 0.039). Our findings suggest that ADIPOR2 rs10773983 polymorphism may be associated with an increased risk of high-normal FPG among non-diabetic Chinese Han subjects who have normal FPG levels.</description><subject>Alleles</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Family Medicine</subject><subject>Fasting</subject><subject>Gene polymorphism</subject><subject>General Practice</subject><subject>Glucose</subject><subject>Health Administration</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Laboratory testing</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Single-nucleotide polymorphism</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kM1KxDAYRYMoOI4-gLuA62h-2qZZDuPPDAgjouuQpmmboSY1SUd8eztUcOXqW9x77gcHgGuCbwnG_C4SlhGMMCkRLihG_AQsiBAlYiWjp2CBBWeICYbPwUWMe4zznBZsAZrV_fZl90rhQQWrXII2QhWj11YlU8MvmzrY2bYzATYqJuta2Paj9tHA3hxMD62DzjtUW1WZZDVcd9aZKd0oBwc_jL1K1rtLcNaoPpqr37sE748Pb-sNet49bderZ6RpUSakuDa5wapiwuSZMZhqpgqia1FS0dRFXfKiERmpdUMqLLRQBJe54kTrjFUsZ0twM-8OwX-OJia592Nw00tJqRAZL1nBpxaZWzr4GINp5BDshwrfkmB51ClnnXLSKY865ZGhMxOnrmtN-Fv-H_oBPRx4UA</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Liu, Na</creator><creator>Yang, Guihua</creator><creator>Hu, Mei</creator><creator>Han, Jing</creator><creator>Cai, Yuyu</creator><creator>Hu, Zhiying</creator><creator>Jia, Chundi</creator><creator>Zhang, Man</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0001-5166-6804</orcidid></search><sort><creationdate>20181001</creationdate><title>ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population</title><author>Liu, Na ; Yang, Guihua ; Hu, Mei ; Han, Jing ; Cai, Yuyu ; Hu, Zhiying ; Jia, Chundi ; Zhang, Man</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-a7ce5e0ab39e54ee02c3a61cd9829fd6d876f941dcf1b09c9a1085a71cc43b353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alleles</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Family Medicine</topic><topic>Fasting</topic><topic>Gene polymorphism</topic><topic>General Practice</topic><topic>Glucose</topic><topic>Health Administration</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Laboratory testing</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Yang, Guihua</creatorcontrib><creatorcontrib>Hu, Mei</creatorcontrib><creatorcontrib>Han, Jing</creatorcontrib><creatorcontrib>Cai, Yuyu</creatorcontrib><creatorcontrib>Hu, Zhiying</creatorcontrib><creatorcontrib>Jia, Chundi</creatorcontrib><creatorcontrib>Zhang, Man</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Na</au><au>Yang, Guihua</au><au>Hu, Mei</au><au>Han, Jing</au><au>Cai, Yuyu</au><au>Hu, Zhiying</au><au>Jia, Chundi</au><au>Zhang, Man</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population</atitle><jtitle>International journal of diabetes in developing countries</jtitle><stitle>Int J Diabetes Dev Ctries</stitle><date>2018-10-01</date><risdate>2018</risdate><volume>38</volume><issue>4</issue><spage>403</spage><epage>408</epage><pages>403-408</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had normal FPG levels. This study included 2038 subjects among the non-diabetic Chinese Han population. The ADIPOR2 polymorphisms were genotyped by the TaqMan method. For the analysis, participants were divided into low-normal FPG group (FPG < 4.88 mmol/L) and high-normal FPG group (6.1 mmol/L > FPG ≥ 4.88 mmol/L). We identified five single nucleotide polymorphisms (SNPs) of ADIPOR2 gene: rs10773989, rs2370055, rs9300298, rs10773983, and rs13611594. There was no significant difference in FPG levels between different genotypes of rs10773989, rs2370055, rs9300298, and rs13611594. Our data showed a significant association of rs10773983 with higher FPG levels, fasting insulin levels, and homeostatic model assessment of insulin resistance (HOMA-IR) in A-allele carriers (
p
= 0.006,
p
< 0.001, and
p
< 0.001, respectively). The subjects in high FPG group had higher median fasting insulin level (9.25 vs 8.16 μIU/mL,
p
= 0.003) and higher HOMA-IR (2.21 vs 1.58,
p
< 0.001) than those in normal FPG group. Subjects with the A-allele of rs10773983 compared to subjects with G-allele had 1.222-fold higher risk for high-normal FPG (OR = 1.222, 95%CI = 1.010–1.478,
p
= 0.039). Our findings suggest that ADIPOR2 rs10773983 polymorphism may be associated with an increased risk of high-normal FPG among non-diabetic Chinese Han subjects who have normal FPG levels.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13410-018-0620-7</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5166-6804</orcidid></addata></record> |
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| subjects | Alleles Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Family Medicine Fasting Gene polymorphism General Practice Glucose Health Administration Insulin Insulin resistance Laboratory testing Medicine Medicine & Public Health Original Article Single-nucleotide polymorphism |
| title | ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population |
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