Treatment Algorithm for Patients With Gastric Adenocarcinoma: An Austrian Consensus on Systemic Therapy

Despite recent advances in the treatment of gastric cancer, mortality related to this disease is still substantial. Surgery and chemotherapy represent the cornerstones of patient management. Targeted treatments that include anti-angiogenic agents and the advent of immunotherapies can contribute to i...

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Bibliographic Details
Published in:Anticancer research 2019-09, Vol.39 (9), p.4589-4596
Main Authors: Wöll, Ewald, Eisterer, Wolfgang, Gerger, Armin, Kühr, Thomas, Prager, Gerald W, Rumpold, Holger, Ulrich-Pur, Herbert, Vogl, Ursula, Winder, Thomas, Weiss, Lukas, Greil, Richard
Format: Article
Language:English
Subjects:
Adenocarcinoma
Algorithms
Angiogenesis
Antiangiogenic agents
Antiangiogenics
Cancer
Chemotherapy
Epidermal growth factor
ErbB-2 protein
Gastric cancer
Growth factors
Immunotherapy
Patients
Surgery
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Summary:Despite recent advances in the treatment of gastric cancer, mortality related to this disease is still substantial. Surgery and chemotherapy represent the cornerstones of patient management. Targeted treatments that include anti-angiogenic agents and the advent of immunotherapies can contribute to improved patient prognosis. Herein, we present an Austrian consensus on the systemic treatment of patients with gastric adenocarcinoma and lower gastroesophageal junction, including those with human epidermal growth factor receptor 2 (HER2)-positive disease. The consensus considers the curative setting, as well as first-line to late-line systemic treatment options in the palliative setting. For HER2-positive disease, first-line and second-line therapies are discussed, as well as HER2 testing. Potential future therapies are also listed, with a focus on anti-angiogenic treatments and checkpoint inhibition, that might provide a further step forward in the management of patients with gastric cancer.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13638