Protein recruitment through indirect mechanochemical interactions

Some of the key proteins essential for important cellular processes are capable of recruiting other proteins from the cytosol to phospholipid membranes. The physical basis for this cooperativity of binding is, surprisingly, still unclear. Here, we suggest a general feedback mechanism that explains c...

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Bibliographic Details
Published in:arXiv.org 2019-10
Main Authors: Goychuk, Andriy, Frey, Erwin
Format: Article
Language:English
Subjects:
Mechanical properties
Membranes
Phospholipids
Proteins
Recruitment
Online Access:Get full text
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Summary:Some of the key proteins essential for important cellular processes are capable of recruiting other proteins from the cytosol to phospholipid membranes. The physical basis for this cooperativity of binding is, surprisingly, still unclear. Here, we suggest a general feedback mechanism that explains cooperativity through mechanochemical coupling mediated by the mechanical properties of phospholipid membranes. Our theory predicts that protein recruitment, and therefore also protein pattern formation, involves membrane deformation, and is strongly affected by membrane composition.
ISSN:2331-8422
DOI:10.48550/arxiv.1910.00977