Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate

We present a multicomponent reaction strategy to synthesize a (dihydro-1H-benzo[d]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves reaction times of only few hours and av...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2019-11, Vol.194 (11), p.1062-1066
Main Authors: Castrejon-Flores, José Luis, Guevara-Moreno, Oscar Ernesto, Díaz-Contreras, Raúl Ricardo, Gutiérrez-Carrillo, Atilano, Franco-Pérez, Marco, Suárez-Moreno, Galdina Vanessa, Zamudio-Medina, Angel
Format: Article
Language:English
Subjects:
Aliphatic amines
Amines
benzimidazoles
Chemical synthesis
diethyl chlorophosphate
Imidazole
Mass spectrometry
Multicomponent reactions
NMR
Nuclear magnetic resonance
Phosphonates
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Summary:We present a multicomponent reaction strategy to synthesize a (dihydro-1H-benzo[d]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves reaction times of only few hours and avoid the usage of any catalyst agent. All the newly synthesized compounds were characterized by Nuclear Magnetic Resonance spectroscopy ( 1 H, 13 C and 31 P) and mass spectrometry by the DART method.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2019.1602834