Serum Antibody to Porphyromonas gingivalis in Chronic Kidney Disease

Potentially significant associations between periodontal disease and chronic kidney disease (CKD) have been reported in recent studies. The aim of this cross-sectional study was to investigate the association between serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis)...

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Bibliographic Details
Published in:Journal of dental research 2012-09, Vol.91 (9), p.828-833
Main Authors: Iwasaki, M., Taylor, G.W., Manz, M.C., Kaneko, N., Imai, S., Yoshihara, A., Miyazaki, H.
Format: Article
Language:English
Subjects:
Age
Aged
Antibodies, Bacterial - blood
Antibody response
Cohort Studies
Cross-Sectional Studies
Enzyme-linked immunosorbent assay
Enzymes
Geriatrics
Glomerular Filtration Rate
Gum disease
Humans
Immunoglobulin G - blood
Kidney diseases
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - immunology
Logistic Models
Odds Ratio
Older people
Periodontal diseases
Population
Porphyromonas gingivalis
Porphyromonas gingivalis - immunology
Risk Factors
Studies
Teeth
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Summary:Potentially significant associations between periodontal disease and chronic kidney disease (CKD) have been reported in recent studies. The aim of this cross-sectional study was to investigate the association between serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) and CKD in 215 Japanese individuals, aged 79 yrs. Serum antibody levels to P. gingivalis were measured by enzyme-linked immunosorbent assay. An elevated serum antibody response was defined as the upper quartile and was compared with the bottom three quartiles. Participants were classified as having CKD when their glomerular filtration rate was between 15 and 59 mL/min/1.73 m2. A multivariable logistic regression model was used to evaluate the association between elevated antibody status and the presence of CKD. Study participants with an elevated serum antibody to P. gingivalis were 2.6 times more likely to have CKD. The adjusted odds ratio of CKD for participants in the highest quartile of serum antibody to P. gingivalis was 2.59 (95% confidence interval, 1.05-6.34) when compared with others in lower quartiles after simultaneous adjustment for other covariates. In conclusion, the present study suggests that elevated serum antibody to P. gingivalis was significantly associated with decreased kidney function in a community-based cohort of elderly Japanese.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034512455063