Serum Antibody to Porphyromonas gingivalis in Chronic Kidney Disease

• Published in: Journal of dental research 2012-09, Vol.91 (9), p.828-833
• Main Authors: Iwasaki, M., Taylor, G.W., Manz, M.C., Kaneko, N., Imai, S., Yoshihara, A., Miyazaki, H.
• Format: Article
• Language: English
• Subjects: Age; Aged; Antibodies, Bacterial - blood; Antibody response; Cohort Studies; Cross-Sectional Studies; Enzyme-linked immunosorbent assay; Enzymes; Geriatrics; Glomerular Filtration Rate; Gum disease; Humans; Immunoglobulin G - blood; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - immunology; Logistic Models; Odds Ratio; Older people; Periodontal diseases; Population; Porphyromonas gingivalis; Porphyromonas gingivalis - immunology; Risk Factors; Studies; Teeth
• ISSN: 0022-0345; 1544-0591
• DOI: 10.1177/0022034512455063

Potentially significant associations between periodontal disease and chronic kidney disease (CKD) have been reported in recent studies. The aim of this cross-sectional study was to investigate the association between serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) and CKD in 215 Japanese individuals, aged 79 yrs. Serum antibody levels to P. gingivalis were measured by enzyme-linked immunosorbent assay. An elevated serum antibody response was defined as the upper quartile and was compared with the bottom three quartiles. Participants were classified as having CKD when their glomerular filtration rate was between 15 and 59 mL/min/1.73 m2. A multivariable logistic regression model was used to evaluate the association between elevated antibody status and the presence of CKD. Study participants with an elevated serum antibody to P. gingivalis were 2.6 times more likely to have CKD. The adjusted odds ratio of CKD for participants in the highest quartile of serum antibody to P. gingivalis was 2.59 (95% confidence interval, 1.05-6.34) when compared with others in lower quartiles after simultaneous adjustment for other covariates. In conclusion, the present study suggests that elevated serum antibody to P. gingivalis was significantly associated with decreased kidney function in a community-based cohort of elderly Japanese.