Impact of folic acid supplementation during pregnancy on cognitive performance of children at age 11 years: preliminary results from the FASSTT Offspring study

For this analysis, test scores of children (for each WISC-IV domain and subtests) were examined in relation to folic acid supplementation of the mother during pregnancy. Furthermore, children (both sexes) of folic acid treated mothers compared to the placebo group had significantly higher mean score...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 2018, Vol.77 (OCE3), Article E98
Main Authors: Caffrey, A., McNulty, H., Irwin, R., Cassidy, T., McLaughlin, M., Lees-Murdock, D., Walsh, C.P., Pentieva, K.
Format: Article
Language:English
Subjects:
Acids
Age
Children
Cognition
Cognition & reasoning
Cognitive ability
Cord blood
Deoxyribonucleic acid
DNA
DNA methylation
Domains
Folic acid
Intelligence tests
Offspring
Pregnancy
Sex
Supplements
Vitamin B
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Summary:For this analysis, test scores of children (for each WISC-IV domain and subtests) were examined in relation to folic acid supplementation of the mother during pregnancy. Furthermore, children (both sexes) of folic acid treated mothers compared to the placebo group had significantly higher mean scores in the Cancellation subtest within Processing Speed: 93·2 (87·0, 99·5) vs 84·7 (77·9, 91·5); (P = 0·035), but not in any other domains or subtests examined (data not shown). [...]the findings of sex-specific effects of folic acid on cognition are also generally consistent with recent epigenetic results in cord blood of these children, which showed sex-specific changes in DNA methylation of genes related to brain development and function(4).
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665118001027