Role of heat stress response in the tolerance of immature renal tubules to anoxia

The stress response was studied in suspensions of tubules from immature (IT) and mature (MT) rats after noninjury, heat, oxygen, and anoxia. Under all conditions, IT exhibited more exuberant activation of heat shock transcription factor (HSF) than MT. Characterization of activated HSF in immature co...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 1998-06, Vol.43 (6), p.F1029-F1036
Main Authors: GAUDIO, K. M, THULIN, G, MANN, A, KASHGARIAN, M, SIEGEL, N. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell physiology
Effects of physical and chemical agents
Fundamental and applied biological sciences. Psychology
Heat
Kidneys
Molecular and cellular biology
Oxygen
Proteins
Ribonucleic acid
RNA
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Summary:The stress response was studied in suspensions of tubules from immature (IT) and mature (MT) rats after noninjury, heat, oxygen, and anoxia. Under all conditions, IT exhibited more exuberant activation of heat shock transcription factor (HSF) than MT. Characterization of activated HSF in immature cortex revealed HSF1. Also, 2 h after each condition, heat shock protein-72 (HSP-72) mRNA was twofold in IT.
ISSN:1931-857X
1522-1466