Long-term regulation of renal Na-dependent cotransporters and ENaC : response to altered acid-base intake

Increased systemic acid intake is associated with an increase in apical Na/H exchange in the renal proximal tubule mediated by the type 3 Na/H exchanger (NHE3). Because NHE3 mediates both proton secretion and Na absorption, increased NHE3 activity could inappropriately perturb Na balance unless ther...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2000-09, Vol.48 (3), p.F459-F467
Main Authors: KIM, Gheun-Ho, MARTIN, Stephen W, FERNANDEZ-LLAMA, Patricia, MASILAMANI, Shyama, PACKER, Randall K, KNEPPER, Mark A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Kidneys
Metabolism
Metabolisms and neurohumoral controls
Potassium
Sodium
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Water and mineral metabolism. Osmoregulation. Acidobasic balance
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Summary:Increased systemic acid intake is associated with an increase in apical Na/H exchange in the renal proximal tubule mediated by the type 3 Na/H exchanger (NHE3). Because NHE3 mediates both proton secretion and Na absorption, increased NHE3 activity could inappropriately perturb Na balance unless there are compensatory changes in Na handling.
ISSN:1931-857X
1522-1466