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Long-term regulation of renal Na-dependent cotransporters and ENaC : response to altered acid-base intake

Increased systemic acid intake is associated with an increase in apical Na/H exchange in the renal proximal tubule mediated by the type 3 Na/H exchanger (NHE3). Because NHE3 mediates both proton secretion and Na absorption, increased NHE3 activity could inappropriately perturb Na balance unless ther...

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Published in:	American journal of physiology. Renal physiology 2000-09, Vol.48 (3), p.F459-F467
Main Authors:	KIM, Gheun-Ho, MARTIN, Stephen W, FERNANDEZ-LLAMA, Patricia, MASILAMANI, Shyama, PACKER, Randall K, KNEPPER, Mark A
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Kidneys Metabolism Metabolisms and neurohumoral controls Potassium Sodium Vertebrates: anatomy and physiology, studies on body, several organs or systems Water and mineral metabolism. Osmoregulation. Acidobasic balance
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container_title	American journal of physiology. Renal physiology
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creator	KIM, Gheun-Ho MARTIN, Stephen W FERNANDEZ-LLAMA, Patricia MASILAMANI, Shyama PACKER, Randall K KNEPPER, Mark A
description	Increased systemic acid intake is associated with an increase in apical Na/H exchange in the renal proximal tubule mediated by the type 3 Na/H exchanger (NHE3). Because NHE3 mediates both proton secretion and Na absorption, increased NHE3 activity could inappropriately perturb Na balance unless there are compensatory changes in Na handling.
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source	American Physiological Society Free
subjects	Biological and medical sciences Fundamental and applied biological sciences. Psychology Kidneys Metabolism Metabolisms and neurohumoral controls Potassium Sodium Vertebrates: anatomy and physiology, studies on body, several organs or systems Water and mineral metabolism. Osmoregulation. Acidobasic balance
title	Long-term regulation of renal Na-dependent cotransporters and ENaC : response to altered acid-base intake
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