Role of PGE2 in alpha2-induced inhibition of AVP- and cAMP-stimulated H2O, N+, and urea transport in rat IMCD

PGE2 inhibits osmotic water permeability (Pf) in the rat inner medullary collecting duct (IMCD) via cellular events occurring after the stimulation of cAMP, i.e., post-cAMP-dependent events. The alpha2-agonists also inhibit Pf in the rat IMCD via post-cAMP-dependent events. The purpose of this study...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2000-08, Vol.48 (2), p.F294
Main Authors: Rouch, Alexander J, Kudo, Lucia H
Format: Article
Language:English
Subjects:
Anatomy & physiology
Kidneys
Permeability
Rodents
Water
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Summary:PGE2 inhibits osmotic water permeability (Pf) in the rat inner medullary collecting duct (IMCD) via cellular events occurring after the stimulation of cAMP, i.e., post-cAMP-dependent events. The alpha2-agonists also inhibit Pf in the rat IMCD via post-cAMP-dependent events. The purpose of this study was to determine whether PGE2 plays a role in alpha2-mediated inhibition of Pf, Na+, and urea transport in the rat IMCD.
ISSN:1931-857X
1522-1466