Vitamin D reduces renal NaPi-2 in PTH-infused rats: complexity of vitamin D action on renal Pi handling

Acute administration of dihydroxycholecalciferol [1,25(OH)2D3] blunts phosphaturia and increases urinary cAMP excretion in parathyroid hormone (PTH)-infused parathyroidectomized (PTX) rats. Because chronic administration of 1,25(OH)2D3 enhances the phosphaturic response to exogenous parathyroid horm...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2001-09, Vol.50 (3), p.F428-F433
Main Authors: FRIEDLAENDER, M. M, WALD, H, DRANITZKI-ELHALEL, M, ZAJICEK, H. K, LEVI, M, POPOVTZER, M. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Kidneys
Rodents
Sodium
Vertebrates: urinary system
Vitamin D
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Summary:Acute administration of dihydroxycholecalciferol [1,25(OH)2D3] blunts phosphaturia and increases urinary cAMP excretion in parathyroid hormone (PTH)-infused parathyroidectomized (PTX) rats. Because chronic administration of 1,25(OH)2D3 enhances the phosphaturic response to exogenous parathyroid hormone despite blunting of urinary cAMP excretion, we have examined the expression of the renal cortex type II Na-Pi cotransporter (NaPi-2) mRNA and protein in 1) chronic PTX Sabra rats, 2) PTX rats receiving a physiological dose of 1,25(OH)-2-D3, 3) PTX rats receiving 35 ng/h of PTH, and 4) rates receiving both PTH and 1,25(OH)2D3, for 7 days via osmotic minipumps.
ISSN:1931-857X
1522-1466