Interleukin-4 and -13 promote basolateral secretion of H+ and cathepsin L by glomerular epithelial cells

Minimal change nephrosis (MCN) is characterized by massive proteinuria and ultrastructural alterations of glomerular visceral epithelial cells (GVEC). MCN has been associated with elevated production of interleukin (IL)-13 by circulating T lymphocytes and with T helper 2 lymphocyte-dependent conditi...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2002, Vol.51 (1), p.F26-F33
Main Authors: VAN DEN BERG, José G, ATEN, Jan, ANNINK, Carla, RAVESLOOT, Jan H, WEBER, Ekkehard, WEENING, Jan J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Kidneys
Vertebrates: urinary system
Online Access:Get full text
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Summary:Minimal change nephrosis (MCN) is characterized by massive proteinuria and ultrastructural alterations of glomerular visceral epithelial cells (GVEC). MCN has been associated with elevated production of interleukin (IL)-13 by circulating T lymphocytes and with T helper 2 lymphocyte-dependent conditions.
ISSN:1931-857X
1522-1466